Papazoglou began performing in a number of Greek local groups in the 1960s. In 1972, he moved to Aachen in Germany with the group Zilotis (Greek: Ζηλωτής) in an attempt to break into the international music scene. The group recorded six songs in Milan, Italy. Shortly afterwards, he returned to Greece.
In 1976, Greek songwriter Dionysis Savvopoulos invited him to participate in Acharnees, a cycle of songs and stage acts based on the ancient comedy by Aristophanes. There Papazoglou met Manolis Rasoulis and the two, along with Dionysis Savvopoulos and Nikos Xydakis, produced in 1978 the influential Ekdikisi Tis Gyftias (Greek: Εκδίκηση της γυφτιάς, meaning The Revenge of Gypsies in Greek). The work received critical acclaim. Papazoglou and Rasoulis cooperated the following year in another successful work, Ta Dithen (Τα δήθεν meaning so-called in Greek).
Since 1984 the artist organized his tours by himself. He and his band known as Loxi falaga (Greek: Λοξή φάλαγγα meaning Oblique order), played in small venues in villages and small islands, gaining huge popularity with the general public. His works generated an ever-expanding audience in northern Europe and America and was very well known as a cult persona with his signature red bandana, the playing of the baglamas and considered a veritable world music figure.
Very well known Nikos Papazoglou songs include: “Κανείς εδώ δεν τραγουδά”, “Αχ Ελλάδα”, “Αύγουστος”, “Οι μάγκες δεν υπάρχουν πια” and “Υδροχόος” as well as many others that have become big Greek and international hits. Many of his songs have been interpreted by other Greek artists and been sung in various languages.
Papazoglou was a producer and sound technician to many of the underground rock scene of Greece in the 1980s through his Agrotikon Studio.
He lived in Thessaloniki with his wife and his two children. He died at 17 April 2011 after a long struggle with cancer.